Distinct population and single-neuron selectivity for executive and episodic processing in human dorsal posterior cingulate. Elife 2022 Sep 28;11
Date
09/29/2022Pubmed ID
36169132Pubmed Central ID
PMC9519147DOI
10.7554/eLife.80722Scopus ID
2-s2.0-85138859591 (requires institutional sign-in at Scopus site) 6 CitationsAbstract
Posterior cingulate cortex (PCC) is an enigmatic region implicated in psychiatric and neurological disease, yet its role in cognition remains unclear. Human studies link PCC to episodic memory and default mode network (DMN), while findings from the non-human primate emphasize executive processes more associated with the cognitive control network (CCN) in humans. We hypothesized this difference reflects an important functional division between dorsal (executive) and ventral (episodic) PCC. To test this, we utilized human intracranial recordings of population and single unit activity targeting dorsal PCC during an alternated executive/episodic processing task. Dorsal PCC population responses were significantly enhanced for executive, compared to episodic, task conditions, consistent with the CCN. Single unit recordings, however, revealed four distinct functional types with unique executive (CCN) or episodic (DMN) response profiles. Our findings provide critical electrophysiological data from human PCC, bridging incongruent views within and across species, furthering our understanding of PCC function.
Author List
Aponik-Gremillion L, Chen YY, Bartoli E, Koslov SR, Rey HG, Weiner KS, Yoshor D, Hayden BY, Sheth SA, Foster BLAuthor
Hernan Gonzalo Rey PhD Assistant Professor in the Neurosurgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BrainBrain Mapping
Cognition
Gyrus Cinguli
Humans
Magnetic Resonance Imaging
Memory, Episodic
Neurons
