Single muscle fibre contractile function with ageing. J Physiol 2022 Dec;600(23):5005-5026
Date
10/22/2022Pubmed ID
36268622Pubmed Central ID
PMC9722590DOI
10.1113/JP282298Scopus ID
2-s2.0-85141777390 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
Ageing is accompanied by decrements in the size and function of skeletal muscle that compromise independence and quality of life in older adults. Developing therapeutic strategies to ameliorate these changes is critical but requires an in-depth mechanistic understanding of the underlying physiology. Over the past 25 years, studies on the contractile mechanics of isolated human muscle fibres have been instrumental in facilitating our understanding of the cellular mechanisms contributing to age-related skeletal muscle dysfunction. The purpose of this review is to characterize the changes that occur in single muscle fibre size and contractile function with ageing and identify key areas for future research. Surprisingly, most studies observe that the size and contractile function of fibres expressing slow myosin heavy chain (MHC) I are well-preserved with ageing. In contrast, there are profound age-related decrements in the size and contractile function of the fibres expressing the MHC II isoforms. Notably, lifelong aerobic exercise training is unable to prevent most of the decrements in fast fibre contractile function, which have been implicated as a primary mechanism for the age-related loss in whole-muscle power output. These findings reveal a critical need to investigate the effectiveness of other nutritional, pharmaceutical or exercise strategies, such as lifelong resistance training, to preserve fast fibre size and function with ageing. Moreover, integrating single fibre contractile mechanics with the molecular profile and other parameters important to contractile function (e.g. phosphorylation of regulatory proteins, innervation status, mitochondrial function, fibre economy) is necessary to comprehensively understand the ageing skeletal muscle phenotype.
Author List
Grosicki GJ, Zepeda CS, Sundberg CWAuthor
Chrisopher Sundberg in the CTSI department at Medical College of Wisconsin - CTSIMESH terms used to index this publication - Major topics in bold
AgedAging
Humans
Muscle Contraction
Muscle Fibers, Skeletal
Muscle, Skeletal
Myosin Heavy Chains
Quality of Life
