Faculty Collaboration Database

A multicenter study to evaluate pain characteristics in osteogenesis imperfecta. Am J Med Genet A 2023 Jan;191(1):160-172

Date

10/23/2022

Pubmed ID

36271817

Pubmed Central ID

PMC10399129

DOI

10.1002/ajmg.a.63009

Scopus ID

2-s2.0-85140724814 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

The objective was to describe pain characteristics and treatments used in individuals with varying severity of osteogenesis imperfecta (OI) and investigate pain-associated variables. This work was derived from a multicenter, longitudinal, observational, natural history study of OI conducted at 12 clinical sites of the NIH Rare Diseases Clinical Research Network's Brittle Bone Disorders Consortium. Children and adults with a clinical, biochemical, or molecular diagnosis of OI were enrolled in the study. We did a cross-sectional analysis of chronic pain prevalence, characteristics, and treatments used for pain relief and longitudinal analysis to find the predictors of chronic pain. We included 861 individuals with OI, in 41.8% chronic pain was present, with similar frequency across OI types. Back pain was the most frequent location. Nonsteroidal anti-inflammatory drugs followed by bisphosphonates were the most common treatment used. Participants with chronic pain missed more days from school or work/year and performed worse in all mobility metrics than participants without chronic pain. The variables more significantly associated with chronic pain were age, sex, positive history of rodding surgery, scoliosis, other medical problems, assistive devices, lower standardized height, and higher body mass index. The predictors of chronic pain for all OI types were age, use of a wheelchair, and the number of fractures/year. Chronic pain is prevalent in OI across all OI types, affects mobility, and interferes with participation. Multiple covariates were associated with chronic pain.

Author List

Rodriguez Celin M, Kruger KM, Caudill A, Murali CN, Nagamani SCS, Members of the Brittle Bone Disorders Consortium (BBDC), Smith PA, Harris GF

Authors

Gerald Harris PhD Director in the Orthopaedic Research Engineering Center (OREC) department at Marquette University
Karen Kruger PhD Research Assistant Professor in the MU-MCW Department of Biomedical Engineering department at Marquette University

MESH terms used to index this publication - Major topics in bold

Adult
Child
Chronic Pain
Cross-Sectional Studies
Diphosphonates
Fractures, Bone
Humans
Osteogenesis Imperfecta