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Chronicity of repeated blast traumatic brain injury associated increase in oxycodone seeking in rats. Behav Brain Res 2023 Feb 13;438:114181



Pubmed ID


Pubmed Central ID




Scopus ID

2-s2.0-85140915448 (requires institutional sign-in at Scopus site)


Numerous epidemiological studies have found co-morbidity between non-severe traumatic brain injury (TBI) and substance misuse in both civilian and military populations. Preclinical studies have also identified this relationship for some misused substances. We have previously demonstrated that repeated blast traumatic brain injury (rbTBI) increased oxycodone seeking without increasing oxycodone self-administration, suggesting that the neurological sequelae of traumatic brain injury can elevate opioid misuse liability. Here, we determined the chronicity of this effect by testing different durations of time between injury and oxycodone self-administration and durations of abstinence. We found that the subchronic (four weeks), but not the acute (three days) or chronic (four months) duration between injury and oxycodone self-administration was associated with increased drug seeking and re-acquisition of self-administration following a 10-day abstinence. Examination of other abstinence durations (two days, four weeks, or four months) revealed no effect of rbTBI on drug seeking at any of the abstinence durations tested. Together, these data indicate that there is a window of vulnerability after TBI when oxycodone self-administration is associated with elevated drug seeking and relapse-related behaviors.

Author List

Chiariello R, McCarthy C, Glaeser BL, Shah AS, Budde MD, Stemper BD, Olsen CM


Matthew Budde PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin
Brian Stemper PhD Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Brain Injuries, Traumatic
Drug-Seeking Behavior
Opioid-Related Disorders
Rats, Sprague-Dawley
Self Administration