MAVRIC based T2 mapping assessment of infrapatellar fat pad scarring in patients with total knee arthroplasty. J Orthop Res 2023 Jun;41(6):1299-1309
Date
10/21/2022Pubmed ID
36262013Pubmed Central ID
PMC10113607DOI
10.1002/jor.25472Scopus ID
2-s2.0-85141489625 (requires institutional sign-in at Scopus site)Abstract
The infrapatellar fat pad (IPFP) has been implicated as a source of postoperative knee pain. Imaging the IPFP is challenging in patients with total knee arthroplasty (TKA) due to metallic susceptibility artifact. Multi-Acquisition Variable-Resonance Image Combination (MAVRIC)-based T2 Mapping has been developed to mitigate this artifact and can generate quantitative T2 data. Objectives of this study were to (1) measure T2 values of the IPFP in patients with TKAs using a MAVRIC based T2 mapping technique and (2) determine if IPFP T2 values are related to the degree of fat pad scarring or clinical magnetic resonance imaging (MRI) findings. Twenty-eight subjects (10 males, 18 females, Age: 66 + 7.2 years [Mean ± standard deviations]) undergoing clinical MRIs were sequentially recruited. Morphological imaging and quantitative T2 mapping sequences were performed on a clinical 1.5 T scanner. The morphologic images were graded for the presence and severity of fat pad scarring and clinical outcomes. T2 values were calculated in the total fat pad volume, a normal regions of interest (ROI), and an abnormal ROI. T2 values were shortened in the total IPFP volume (p = 0.001) and within abnormal regions (p = 0.003) in subjects with more severe IPFP scarring. The difference between T2 values in normal-abnormal regions was greater in subjects with severe versus no scarring (+1426.1%, p = 0.008). T2 values were elevated in patients with MRI findings of osteolysis (+32.3%, p = 0.02). These findings indicate that MAVRIC-based T2 Mapping may be used as a quantitative biomarker of postoperative IPFP scarring in individuals following TKA.
Author List
Sacher SE, Neri JP, Gao MA, Argentieri EC, Potter HG, Koch KM, Koff MFAuthor
Kevin M. Koch PhD Center Director, Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adipose TissueAged
Arthroplasty, Replacement, Knee
Female
Humans
Knee Joint
Magnetic Resonance Imaging
Male
Middle Aged
Osteoarthritis, Knee
Pain, Postoperative
