Faculty Collaboration Database

Effect of pulmonary embolism response team on advanced therapies administered: The University of Michigan experience. Thromb Res 2023 Jan;221:73-78

Date

12/10/2022

Pubmed ID

36493540

Pubmed Central ID

PMC10353850

DOI

10.1016/j.thromres.2022.11.017

Scopus ID

2-s2.0-85143890305 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

BACKGROUND: Pulmonary Embolism Response Teams (PERT) were employed at multiple institutions to bridge the gap between varied treatment options for acute PE and unclear evidence for optimal management. There is limited data regarding the impact of PERT on the use of advanced therapies and clinical outcomes.

METHODS: We performed a retrospective single-center cohort study comparing patients that presented to the ED with an acute PE before and after the creation of PERT in June 2017 at our institution. We assessed utilization of advanced therapies, LOS, and mortality.

RESULTS: A total of 817 patients (168 pre-PERT, 649 post-PERT) were evaluated in the ED with an acute PE between October 2016 and December 2019. Both groups were similar in demographics, comorbidities, and PESI score. There was a decrease in advanced therapy use (16 % vs. 7.5 %, p = 0.006) after PERT creation. Most notable decreases were in catheter-based therapies (8.5 % vs. 2.2 %, p = 0.008) and IVC filter placement (5.3 % vs. 3.2 %, p < 0.001). Median ICU LOS (2.5 days vs. 2.3 days, p = 0.55) and hospital LOS (3.1 vs. 3.0, p = 0.92) did not vary pre-PERT vs. post-PERT. In-hospital mortality (8.5 % vs. 5.0 %, p = 0.29) and 30-day all-cause mortality (1.2 % vs. 0.5 %, p = 0.28) were not different between the two groups as well.

CONCLUSION: At our institution, PERT was associated with a decrease in advanced therapies administered to acute PE patients without affecting mortality or LOS. Additional studies to assess impact of this multi-disciplinary care team model on interventional therapies and clinical outcomes for PE at a broader level are necessary.

Author List

Ardeshna NS, Song M, Hyder SN, Grace KA, O'Hare C, Schaeffer WJ, Stover M, Greineder CF, Barnes GD

Author

William J. Schaeffer DO Assistant Professor in the Emergency Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cohort Studies
Humans
Patient Care Team
Pulmonary Embolism
Retrospective Studies
Thrombolytic Therapy