Molecular and immunohistochemical testing of bone tumours: review and update. Histopathology 2023 May;82(6):794-811
Date
11/26/2022Pubmed ID
36424903DOI
10.1111/his.14845Scopus ID
2-s2.0-85143980937 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Primary bone tumours can pose diagnostic problems due to their overlapping radiologic and histologic features. Given the recent advancement in our understanding of the biology of bone tumours, multiple immunohistochemical and molecular markers have been devised to aid in their diagnosis. This review provides brief updates on select bone tumours, including chondrosarcomas, benign chondrogenic tumours, osteosarcomas, benign osteogenic tumours, fibroosseous lesions, vascular tumours, osteoclastic giant cell-rich or cystic tumours, chordoma, adamantinoma, small round blue cell sarcomas, and others. We discuss their salient molecular features and novel immunohistochemical correlates, along with some tips to avoid common diagnostic pitfalls.
Author List
Kovacs SK, Manassaporn A, Nielsen GP, Hung YPAuthor
Sandor K. Kovacs MD Assistant Professor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Bone NeoplasmsBone and Bones
Chondrosarcoma
Humans
Osteosarcoma
Sarcoma, Small Cell
