Faculty Collaboration Database

Relationship Between Cerebrospinal Fluid Protein Levels and Electrophysiologic Abnormalities in Guillain-Barré Syndrome. J Clin Neuromuscul Dis 2015 Dec;17(2):47-51

Date

11/20/2015

Pubmed ID

26583489

DOI

10.1097/CND.0000000000000091

Scopus ID

2-s2.0-84948466187 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

OBJECTIVES: The cerebrospinal fluid (CSF) protein level is known to be elevated in patients with Guillain-Barré syndrome (GBS). This report correlates the degree of CSF protein elevation with the number of electrophysiologic abnormalities on nerve conduction study (NCS).

METHODS: We reviewed 38 patients admitted to our institution with a diagnosis of GBS and had both a measured CSF protein level and a NCS within 24 hours of each other.

RESULTS: CSF protein level correlates with the number of NCS demyelination criteria, as described by Cornblath, in patients with GBS.

CONCLUSIONS: This retrospective study is the first to demonstrate a relationship between the CSF protein level and the electrophysiologic abnormalities that accompany GBS.

Author List

DiCapua DB, Lakraj AA, Nowak RJ, Robeson K, Goldstein J, Patwa H

Author

Amrita-Amanda D. Vuppala MD Assistant Professor in the Ophthalmology and Visual Sciences department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Analysis of Variance
Electrophysiology
Female
Guillain-Barre Syndrome
Humans
Male
Neural Conduction
Proteins
Retrospective Studies
Young Adult