Effect of sodium ion coupled nutrient transport on intestinal permeability in chronically catheterised rats. Gut 1998 Jul;43(1):22-8
Date
10/15/1998Pubmed ID
9771401Pubmed Central ID
PMC1727170DOI
10.1136/gut.43.1.22Scopus ID
2-s2.0-0031813716 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
BACKGROUND: The significance of Nanutrient cotransport induced alterations in paracellular permeability is controversial. Most previous studies have measured intestinal permeability using in vitro methods or in vivo methods immediately after surgical bowel manipulation, and therefore may not be applicable to normal physiological conditions.
AIMS: To determine whether activation of Na coupled nutrient transport increases intestinal permeability under normal physiological conditions.
METHODS: The effect of Na-nutrient cotransport on intestinal permeability was measured in unrestrained, unanaesthetised, chronically catheterised male Sprague-Dawley rats using two different methods: measurement of the rate of absorption of passively absorbed hexoses, mannitol and L-glucose; and measurement of the mannitol:urea diffusion ratio.
RESULTS: L-Glucose and mannitol absorption were not increased in the presence of D-glucose, alanine, maltose, or peptides. The mannitol:urea diffusion ratio was not increased by the presence of D-glucose. The presence of D-glucose in the intestinal lumen for 20 minutes did not alter intestinal permeability.
CONCLUSIONS: Under normal physiological conditions, Na coupled nutrient transport does not increase intestinal permeability.
Author List
Uhing MRAuthor
Michael R. Uhing MD Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBiological Transport
Dietary Sucrose
Diffusion
Glucose
Intestinal Absorption
Male
Mannitol
Rats
Rats, Sprague-Dawley
Sodium
Urea
