Pharmacological stimulation of arterial chemoreceptors in conscious rats produces differential responses in renal cortical and medullary blood flow. Clin Exp Pharmacol Physiol 1998;25(7-8):536-40
Date
07/23/1998Pubmed ID
9673424DOI
10.1111/j.1440-1681.1998.tb02247.xScopus ID
2-s2.0-0031827496 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
1. There have been no previously published data regarding intrarenal blood flow distribution in acute whole-body hypoxic hypoxia and/or arterial chemoreceptor stimulation in normoxic mammals. 2. Cortical and medullary blood flows were measured simultaneously before and in response to pharmacological stimulation of peripheral arterial chemoreceptors by i.v. injection of almitrine bismesylate (0.25 mg/kg). 3. Arterial chemoreceptor excitation reduced cortical blood flow but only in innervated kidneys. An effect on medullary blood flow was observed in neither innervated nor denervated kidneys. 4. These data indicate that renal cortical and medullary blood flows react differently to arterial chemoreceptor stimulation.
Author List
Ledderhos C, Gross V, Cowley AW JrAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlmitrineAnimals
Arteries
Blood Pressure
Chemoreceptor Cells
Denervation
Heart Rate
Kidney
Kidney Cortex
Kidney Medulla
Male
Norepinephrine
Rats
Rats, Sprague-Dawley
Renal Circulation
Respiratory System Agents
Stimulation, Chemical
Vasoconstrictor Agents
