Case report: Two unique cases of co-existing primary brain tumors of glial origin in opposite hemispheres. Front Oncol 2022;12:1018840
Date
12/27/2022Pubmed ID
36568179Pubmed Central ID
PMC9771729DOI
10.3389/fonc.2022.1018840Scopus ID
2-s2.0-85144424557 (requires institutional sign-in at Scopus site) 1 CitationAbstract
BACKGROUND: Primary CNS tumors are rare. Coexistence of two glial tumors of different histological origins in the same patient is even rarer. Here we describe two unique cases of coexisting distinct glial tumors in opposite hemispheres.
CASES: Patient 1 is a 38-year-old male who presented with a seizure in February/2016. MRI showed a left parietal and a right frontal infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and an astrocytoma WHO grade-2. Patient 2 is a 34-year-old male who presented with a seizure in November/2021. MRI showed a left frontal and a right mesial temporal lobe infiltrating nonenhancing lesions. Both lesions were resected revealing an oligodendroglioma WHO grade-2 and a diffuse low-grade glioma, MAPK pathway-altered (BRAF V600E-mutant). Patient 1 underwent adjuvant treatment. Both patients are without recurrence to date.
DISCUSSION: Two histologically distinct glial tumors may coexist, especially when they are non-contiguous. Pathological confirmation of each lesion is imperative for appropriate management. We highlight the different management of gliomas based on the new CNS WHO 2021 classification compared to its 2016 version, based on NCCN guidelines. Although more molecular markers are being incorporated into glioma classification, their clinical impact of it is yet to be determined.
Author List
Singhal I, Coss D, Mueller W, Straza M, Krucoff MO, Santos-Pinheiro FAuthors
Max O. Krucoff MD Assistant Professor in the Neurosurgery department at Medical College of WisconsinWade M. Mueller MD Professor in the Neurosurgery department at Medical College of Wisconsin
Michael W. Straza MD, PhD Assistant Professor in the Radiation Oncology department at Medical College of Wisconsin
