Faculty Collaboration Database

Dyspnea in a patient with Mounier-Kuhn syndrome. J Bronchology Interv Pulmonol 2012 Apr;19(2):145-8

Date

12/05/2012

Pubmed ID

23207360

DOI

10.1097/LBR.0b013e318253181f

Scopus ID

2-s2.0-84863651156 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Poorly differentiated non-small cell lung carcinoma with a component of sarcoma-like (spindle and/or giant cells) or sarcoma (malignant bone, cartilage, or skeletal muscle) cells are called pleomorphic carcinoma. These carcinoma represent one of the 5 subtypes of rare pulmonary malignancies collectively classified as sarcomatoid carcinoma by the World Health Organization histologic classification of lung tumors. The pathogenesis of sarcomatoid carcinoma remains unclear, and treatment of this malignant tumor is less defined. Very few cases of sarcomatoid carcinoma involving the upper respiratory tract have been reported in the literature. We report here an atypical presentation and location of this tumor (in the trachea), causing obstruction with a positional ball-valve effect, in a patient with tracheobronchomegaly (Mounier-Kuhn syndrome). In addition, we discuss the recurrent nature of the disease and the potential therapeutic difficulties.

Author List

Puthalapattu S, Udoji TN, Bechara RI, Ioachimescu OC

Author

Octavian C. Ioachimescu MD, PhD Vice Chair, Director, Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Airway Obstruction
Dyspnea
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Neoplasms, Complex and Mixed
Respiratory Sounds
Tracheal Neoplasms
Tracheobronchomegaly