Hepatopulmonary syndrome following portopulmonary hypertension. Eur Respir J 2007 Jun;29(6):1277-80
Date
06/02/2007Pubmed ID
17540789DOI
10.1183/09031936.00140306Scopus ID
2-s2.0-34250189526 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Portopulmonary hypertension (PPHTN) and hepatopulmonary syndrome (HPS) are distinct clinical entities that may accompany liver disease. While PPHTN and HPS have been infrequently described as occurring in the same patient, to the present authors' knowledge, the order of occurrence has always been the initial onset of HPS, with pulmonary hypertension developing either concurrently or subsequently. In some instances, liver transplantation has been undertaken for HPS, followed by resolution of the HPS and subsequent development of pulmonary hypertension. The current case study presents a patient with hepatitis C-related cirrhosis in whom PPTHN developed initially, followed 2 yrs later by the development of the HPS. The current authors speculate that progressive imbalance in favour of endogenous vasodilators over vasoconstrictive factors led to normalisation of the pulmonary artery pressures.
Author List
Ioachimescu OC, Mehta AC, Stoller JKAuthor
Octavian C. Ioachimescu MD, PhD Vice Chair, Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedBlood Gas Analysis
Echocardiography
Fibrosis
Hepatitis C
Hepatopulmonary Syndrome
Humans
Hypertension
Hypertension, Portal
Hypertension, Pulmonary
Liver Diseases
Male
Treatment Outcome
Vasoconstrictor Agents
Vasodilator Agents
