From cystic pulmonary airway malformation, to bronchioloalveolar carcinoma and adenocarcinoma of the lung. Eur Respir J 2005 Dec;26(6):1181-7
Date
12/02/2005Pubmed ID
16319347DOI
10.1183/09031936.05.00011705Scopus ID
2-s2.0-29244490089 (requires institutional sign-in at Scopus site) 87 CitationsAbstract
Bronchioloalveolar carcinoma (BAC) of the lungs is a known morphological subtype of nonsmall cell cancer. The current study presents several carcinogenetic theories of BAC and the possible relationship with atypical adenomatous hyperplasia and congenital pulmonary airway malformation (CPAM). The authors present an unusual case of BAC developed in an area of CPAM, with subsequent progression to metastatic adenocarcinoma (AC). The case is unique due to the combination of: early age of presentation; neoplastic transformation of a CPAM; unaltered course over 15 yrs; and its particular pattern of slow morphogenesis and degeneration into an invasive AC of the lung. The case also presents the unique features of a long-standing, unaltered natural course of paediatric BAC towards invasive and metastatic AC, illustrating that lack of growth over many years cannot be entirely trusted as a criterion of benignity. In conclusion, clinicians and pathologists need to be aware of the fact that congenital pulmonary airway malformation so far represents the only known pre-invasive lesion for mucinous bronchioloalveolar carcinoma.
Author List
Ioachimescu OC, Mehta ACAuthor
Octavian C. Ioachimescu MD, PhD Vice Chair, Director, Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdenocarcinomaAdenocarcinoma, Bronchiolo-Alveolar
Adult
Biopsy, Needle
Cell Transformation, Neoplastic
Cystic Adenomatoid Malformation of Lung, Congenital
Follow-Up Studies
Humans
Immunohistochemistry
Lung Neoplasms
Male
Precancerous Conditions
Risk Assessment
Thoracoscopy
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
