Association between myopia progression and quantity of laser treatment for retinopathy of prematurity. PLoS One 2022;17(12):e0279898
Date
12/31/2022Pubmed ID
36584135Pubmed Central ID
PMC9803142DOI
10.1371/journal.pone.0279898Scopus ID
2-s2.0-85145425573 (requires institutional sign-in at Scopus site)Abstract
BACKGROUND: Previous studies found that infants with retinopathy of prematurity (ROP) who were treated for more posterior disease with a greater number of laser spots developed higher myopia. These studies included multiple physicians with variations in laser density. In treatments by a single physician, laser spot count is a better surrogate for area of avascular retina and anterior-posterior location of disease, so that the relationship with myopia can be better assessed.
METHODS: Our retrospective study included infants treated with laser for ROP by a single surgeon at a single center. Exclusion criteria were irregularities during laser and additional treatment for ROP. We assessed correlation between laser spot count and change in refractive error over time using a linear mixed effects model.
RESULTS: We studied 153 eyes from 78 subjects treated with laser for ROP. The average gestational age at birth was 25.3±1.8 weeks, birth weight 737±248 grams, laser spot count 1793±728, and post-treatment follow up 37±29 months. Between corrected ages 0-1 years, the mean spherical equivalent was +0.4±2.3 diopters; between ages 1-2, it was -1.3±3.2D; and ages 2-3 was -0.8±3.1D. Eyes that received more laser spots had significantly greater change in refractive error over time (0.30D more myopia per year per 1000 spots). None of the eyes with hyperopia before 18 months developed myopia during the follow-up period.
CONCLUSIONS: Greater myopia developed over time in infants with ROP treated by laser to a larger area of avascular retina.
Author List
Hwang ES, Kassem IS, Allozi R, Kravets S, Al-Kirwi KY, Hallak JA, Costakos DMAuthor
Deborah M. Costakos MD Chair, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Child, PreschoolGestational Age
Humans
Infant
Infant, Newborn
Laser Coagulation
Myopia
Refractive Errors
Retina
Retinopathy of Prematurity
Retrospective Studies
Treatment Outcome
