Lipofibromatosis-like neural tumors: Report of a case and review of 73 reported cases. Pediatr Dermatol 2023;40(4):664-668
Date
01/10/2023Pubmed ID
36617686DOI
10.1111/pde.15218Scopus ID
2-s2.0-85146077982 (requires institutional sign-in at Scopus site) 1 CitationAbstract
Lipofibromatosis-like neural tumors (LPF-NTs) are a recently discovered group of spindle cell tumors defined by the presence of a lipofibromatosis-like pattern, CD34 and/or S100 reactivity, and frequent neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangements. As new cases emerge, the spectrum of features observed in LPF-NTs continues to evolve. Here we describe the case of an 11-year-old with LPF-NT with a dermatofibrosarcoma protuberans-like honeycomb pattern, CD34 and S100 co-expression, and an NTRK1 rearrangement. We also review the clinical and molecular features of the 73 cases of LPF-NT previously described in the literature.
Author List
Ulschmid CM, Singam V, Segura A, Gourlay DM, Chiu YEAuthors
Yvonne E. Chiu MD Vice Chair, Professor in the Dermatology department at Medical College of WisconsinDavid M. Gourlay MD Chief, Professor in the Surgery department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Biomarkers, TumorChild
Fibroma
Humans
Skin Neoplasms
Soft Tissue Neoplasms
