Faculty Collaboration Database

Evidence for a renal alpha-adrenergic receptor inhibiting renin release. Circ Res 1976 May;38(5):338-46

Date

05/01/1976

Pubmed ID

5201

DOI

10.1161/01.res.38.5.338

Scopus ID

2-s2.0-0017140649 (requires institutional sign-in at Scopus site)   125 Citations

Abstract

The mechanism by which clonidine suppresses renin release was investigated in conscious rats. This suppression was studied by means of selected autonomic interventions in conjunction with changes in sodium balance. Serum renin activity and direct arterial pressure were monitored. Clonidine administration suppressed basal (by 68-85%), diuretic-induced (by 89%), and sympathetic nervous system-mediated (by 75-100%) renin release. Cholinergic, ganglionic, and peripheral sympathetic neuronal blockade did not prevent this inhibitory effect of clonidine. These results indicate a peripheral site of action for suppression of renin release by clonidine. The alpha-adrenergic blocking drug phentolamine prevented clonidine suppression of renin release in sodium-depleted rats and was partially effective in normal rats. Phentolamine blocked the decrease in renin caused by clonidine in ganglion-blocked rats. Clozapine, a new neuroleptic agent with alpha-adrenergic blocking activity, or phenoxybenzamine blocked the effect of clonidine on renin release in both sodium-depleted and normal rats. After ganglionic blockade in sodium-depleted rats, clonidine caused a significantly greater suppression of renin release than did an equipressor dose of methoxamine. These data, combined with hemodynamic correlates, suggest that clonidine inhibits renin release by activation of an intrarenal alpha-adrenergic receptor.

Author List

Pettinger WA, Keeton TK, Campbell WB, Harper DC

Author

William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adrenergic alpha-Antagonists
Animals
Blood Pressure
Chlorisondamine
Clonidine
Clozapine
Hyponatremia
Juxtaglomerular Apparatus
Male
Methoxamine
Phenoxybenzamine
Phentolamine
Propranolol
Rats
Receptors, Adrenergic
Renin
Sympathetic Nervous System