Renin and hemodynamic changes via central adrenergic, cholinergic, and sodium receptor mechanisms in conscious rats. Proc Soc Exp Biol Med 1976 Jan;151(1):101-4
Date
01/01/1976Pubmed ID
2926DOI
10.3181/00379727-151-39152Scopus ID
2-s2.0-0017254035 (requires institutional sign-in at Scopus site) 20 CitationsAbstract
The effects of centrally administered autonomic drugs and hypertonic saline on renin release were studied in the conscious rat. A 0.3 mug intraventricular dose of isoproterenol, which is one-thirtieth of the intraperitoneal dose required to stimulate renin release, induced the release of renin into the systemic circulation. Norepinephrine had no effect on renin release in the same dose range. Hypertonic saline and carbachol suppressed renin release. Alterations in renin release were preceded by a reciprocal change in blood pressure. These results suggest a central nervous system site for sodium, beta-adrenergic, and cholinergic receptors in altering renin release and blood pressure.
Author List
Morris M, Campbell WB, Pettinger WAAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Adrenergic AgonistsAnimals
Blood Pressure
Brain
Carbachol
Dose-Response Relationship, Drug
Injections, Intraventricular
Isoproterenol
Male
Norepinephrine
Parasympathomimetics
Rats
Receptors, Adrenergic
Receptors, Cholinergic
Receptors, Drug
Renin
Sodium
Sodium Chloride
