Renin release, an artifact of anesthesia and its implications in rats. Proc Soc Exp Biol Med 1975 Mar;148(3):625-30
Date
03/01/1975Pubmed ID
1129282DOI
10.3181/00379727-148-38597Scopus ID
2-s2.0-0016800132 (requires institutional sign-in at Scopus site) 90 CitationsAbstract
In our attempt to find an anesthetic agent which did not influence the renin-angiotensin system in the rat, the effect of widely used injectable and gaseous anesthetics and narcotic agents on renin release was chacterized. All of the agents studied induced dose- and time-related increases in serum renin activity when administered in anesthetic doses. Preliminary experiments in anesthetic doses. Preliminary experiments indicated that cardiovascular effects were highly variable, giving little insight into the relationship between renin release and cardiovascular changes. Propranolol impaired most of the anesthesia-induced renin release and impaired aldosterone release with the one agent (urethane) studied. Renin release by two anesthetic agents (ketamine and urethane) appeared to be mediated premarily through the beta-adrenermediated primarily through the beta-adrenergic receptor mechanism, but equivocal results were obtained with other agents (pentobarbital and morphine). It is possible that other anesthetics, as with urethane, may induce aldosterone release by way of renin release. This anesthesia-induced renin release and the extensive biologic activities of angiotensin and aldosterone suggest a potential for influencing many investigations, particularly those involving cardiovascular and endocrine systems.
Author List
Pettinger WA, Tanaka K, Keeton K, Campbell WB, Brooks SNAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AldosteroneAnesthesia, Inhalation
Anesthesia, Intravenous
Anesthetics
Animals
Blood Pressure
Chloralose
Cyclopropanes
Ethyl Ethers
Halothane
Heart Rate
Ketamine
Male
Methoxyflurane
Morphine
Nitrous Oxide
Pentobarbital
Propranolol
Rats
Renin
Urethane
