Clinical burden of illness in patients with neuroendocrine tumors. Pancreas 2012 Oct;41(7):1058-62
Date
04/20/2012Pubmed ID
22513292DOI
10.1097/MPA.0b013e318249d8f7Scopus ID
2-s2.0-84865863959 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
OBJECTIVE: The objective of this study was to evaluate the incremental risk of morbidities affecting the cardiovascular, hepatic, gastrointestinal, skeletal, and neuropsychiatric systems in patients with neuroendocrine tumors (NETs) compared with a noncancer cohort.
METHODS: In a retrospective, matched-control study using US claims databases, noncancer control subjects (n = 3524) were matched 2:1 with patients with newly diagnosed NET (n = 1762) on age, sex, region, hospital data availability, and index year. Rates of select morbidities were compared between patients with NET and control subjects. Incremental risks were analyzed using logistic regressions adjusting for baseline characteristics.
RESULTS: In the first 3 years after diagnosis in patients with NET versus matched control subjects without cancer, (1) the adjusted risk of cardiovascular morbidities was higher (odds ratio [OR], 1.26; P = 0.0206); (2) the adjusted risk of hepatic or gastrointestinal morbidities was higher (OR, 1.95, P < 0.0001); (3) the adjusted risk of osteoporosis/osteopenia was higher among those 50 years or younger (OR, 3.24; P = 0.0081); and (4) the adjusted risk of anxiety/depression was higher among those 65 years or younger (OR, 1.48; P = 0.0210).
CONCLUSIONS: Patients with NET have greater clinical burden of disease than matched control subjects with respect to conditions affecting the cardiovascular, hepatic, and gastrointestinal systems. Excess clinical burden of disease with respect to anxiety, depression, osteoporosis, and osteopenia was observed in patients with NET in the younger age groups.
Author List
Hess GP, Chen CC, Liu Z, Yao JC, Phan AT, Hill JWAuthor
Alexandria T. Phan MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedAnxiety
Cardiovascular Diseases
Cost of Illness
Depression
Female
Gastrointestinal Diseases
Humans
Liver Diseases
Logistic Models
Male
Middle Aged
Multivariate Analysis
Neuroendocrine Tumors
Odds Ratio
Osteoporosis
Retrospective Studies
Risk Factors
