Comparison of health-related quality of life in patients with neuroendocrine tumors with quality of life in the general US population. Pancreas 2012 Apr;41(3):461-6
Date
03/17/2012Pubmed ID
22422138DOI
10.1097/MPA.0b013e3182328045Scopus ID
2-s2.0-84859060426 (requires institutional sign-in at Scopus site) 144 CitationsAbstract
OBJECTIVE: The objective of this study was to evaluate the health-related quality of life (HRQL) burden of patients with neuroendocrine tumor (NET) and associations with demographic and clinical factors.
METHODS: Patients with NET were invited to participate in an online, anonymous survey consisting of 2 standardized HRQL measures, SF-36 and PROMIS-29, and a set of demographic and disease-related questions. General linear models were used to evaluate the associations between HRQL and demographic and clinical characteristics.
RESULTS: A total of 663 patients participated. These patients with NET demonstrated worse HRQL scores compared to the general population and to a sample of mixed cancer patients and survivors. Patients with current NET (tumor not surgically removed or came back after surgery), carcinoid syndrome, or an increased number of bowel movements or flushing episodes experience worsened HRQL compared to patients with NET without those characteristics after adjustment for other clinical and demographic variables.
CONCLUSIONS: Patients with NET reported worse HRQL scores compared to the general population. NET-related symptoms such as diarrhea and flushing were associated with reduced quality of life in this cross-sectional study. Optimal management of NET and carcinoid syndrome may significantly improve HRQL among patients with NETs.
Author List
Beaumont JL, Cella D, Phan AT, Choi S, Liu Z, Yao JCAuthor
Alexandria T. Phan MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Case-Control StudiesCost of Illness
Cross-Sectional Studies
Diarrhea
Female
Flushing
Health Surveys
Humans
Internet
Linear Models
Male
Malignant Carcinoid Syndrome
Middle Aged
Multivariate Analysis
Neuroendocrine Tumors
Quality of Life
Surveys and Questionnaires
United States
