Simulating the Evolution of Signaling Signatures during CART-Cell - Tumor Cell Interactions. ArXiv 2023 Feb 08
Date
02/18/2023Pubmed ID
36798455Pubmed Central ID
PMC9934731Abstract
Immunotherapies have been proven to have significant therapeutic efficacy in the treatment of cancer. The last decade has seen adoptive cell therapies, such as chimeric antigen receptor T-cell (CART-cell) therapy, gain FDA approval against specific cancers. Additionally, there are numerous clinical trials ongoing investigating additional designs and targets. Nevertheless, despite the excitement and promising potential of CART-cell therapy, response rates to therapy vary greatly between studies, patients, and cancers. There remains an unmet need to develop computational frameworks that more accurately predict CART-cell function and clinical efficacy. Here we present a coarse-grained model simulated with logical rules that demonstrates the evolution of signaling signatures following the interaction between CART-cells and tumor cells and allows for in silico based prediction of CART-cell functionality prior to experimentation.
Author List
Shah V, Womack J, Zamora AE, Terhune SS, Dash RKAuthors
Ranjan K. Dash PhD Professor in the Biomedical Engineering department at Medical College of WisconsinScott Terhune PhD Professor in the Microbiology and Immunology department at Medical College of Wisconsin
Anthony E. Zamora PhD Assistant Professor in the Medicine department at Medical College of Wisconsin
