A Case of Fabry Disease With Lacrimal Gland Involvement. Ophthalmic Plast Reconstr Surg 2023 Mar-Apr 01;39(2):e52-e55
Date
02/03/2023Pubmed ID
36728127DOI
10.1097/IOP.0000000000002312Scopus ID
2-s2.0-85149874340 (requires institutional sign-in at Scopus site)Abstract
Fabry disease is an X-linked lysosomal storage disease resulting from an error in the glycosphingolipid metabolic pathway, which leads to accumulation of globotriaosylceramide in lysosomes of the skin, kidneys, heart, brain, and other organs. There are no existing reports of histologically proven lacrimal gland involvement in Fabry disease. The authors report the case of a 26-year-old male with Fabry disease who presented with bilateral upper eyelid dermatochalasis, steatoblepharon, and prolapsed lacrimal glands. The patient underwent surgical repair of the upper eyelids and biopsy of the lacrimal glands. The pathologic assessment demonstrated lamellated intracytoplasmic inclusions characteristic of Fabry disease. The prevalence of globotriaosylceramide lacrimal gland deposition in Fabry disease and the effect on lacrimal gland morphology and function have yet to be determined.
Author List
Bruce CN, Mancera N, Grover A, Esmaili NAuthor
Neda Esmaili MD Associate Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFabry Disease
Humans
Lacrimal Apparatus
Male
Skin
Trihexosylceramides
