The "oldest and coldest" shipped living donor kidneys transplanted through kidney paired donation. Am J Transplant 2020 Jan;20(1):137-144
Date
07/07/2019Pubmed ID
31278819Pubmed Central ID
PMC7010231DOI
10.1111/ajt.15527Scopus ID
2-s2.0-85070911206 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
To date, thousands of living donor kidneys have been shipped through kidney paired donation (KPD). To expand on this growing segment of living donor transplantation, we evaluated the effect of advanced age donation ("oldest kidneys") and prolonged cold ischemia time ("coldest kidneys") on graft function and survival using the National Kidney Registry database from February 2008 to May 2018. Donors were stratified by age at time of donation (<65 or ≥65 years) and kidneys were stratified by cold ischemia time (<16 or ≥16 hours). We evaluated delayed graft function and death-censored graft failure (DCGF) for up to seven posttransplant years. Of the 2363 shipped living donor kidney transplants, 4.1% of donors were ≥65 years and 6.0% of transplanted kidneys had cold ischemia times ≥16 hours. Delayed graft function and DCGF occurred in 5.2% and 4.7% of cases. There were no significant associations between delayed graft function and donor age (P = .947) or cold ischemia (P = .532). Donor age and cold ischemia time were not predictive of delayed graft function (OR = 0.86,1.20; P = .8, .6) or DCGF (HR = 1.38,0.35, P = .5, .1). These findings may alleviate concerns surrounding the utilization of kidneys from older donors or those originating from distant transplant centers.
Author List
Nassiri N, Kwan L, Bolagani A, Thomas AG, Sinacore J, Ronin M, Cooper M, Segev DL, Cecka JM, Veale JLAuthor
Matthew Cooper MD Chief, Director, Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Cold Ischemia
Delayed Graft Function
Female
Follow-Up Studies
Graft Rejection
Graft Survival
Humans
Kidney Failure, Chronic
Kidney Transplantation
Living Donors
Male
Middle Aged
Organ Preservation
Prognosis
Registries
Risk Factors
Survival Rate
Tissue and Organ Harvesting
Transportation
Young Adult
