Faculty Collaboration Database

3D magnetic resonance fingerprinting for rapid simultaneous T1, T2, and T1ρ volumetric mapping of human articular cartilage at 3 T. NMR Biomed 2022 Dec;35(12):e4800

Date

07/12/2022

Pubmed ID

35815660

Pubmed Central ID

PMC9669203

DOI

10.1002/nbm.4800

Scopus ID

2-s2.0-85135119841 (requires institutional sign-in at Scopus site)   12 Citations

Abstract

Quantitative MRI can detect early biochemical changes in cartilage; however, the conventional techniques only measure one parameter (e.g., T₁ , T₂ , and T_1ρ ) at a time while also being comparatively slow. We implemented a 3D magnetic resonance fingerprinting (3D-MRF) technique for simultaneous, volumetric mapping of T₁ , T₂ , and T_1ρ in knee articular cartilage in under 9 min. It is evaluated on 11 healthy volunteers (mean age: 53 ± 9 years), five mild knee osteoarthritis (OA) patients (Kellgren-Lawrence (KL) score: 2, mean age: 60 ± 4 years), and the National Institute of Standards and Technology (NIST)/International Society for Magnetic Resonance in Medicine (ISMRM) system phantom. Proton density image, and T₁ , T_2, T_1ρ relaxation times, and B₁ ⁺ were estimated in the NIST/ISMRM system phantom as well as in the human knee medial and lateral femur, medial and lateral tibia, and patellar cartilage. The repeatability and reproducibility of the proposed technique were assessed in the phantom using analysis of the Bland-Altman plots. The intrasubject repeatability was assessed with the coefficient of variation (CV) and root mean square CV (rmsCV). The Mann-Whitney U test was used to assess the difference between healthy subjects and mild knee OA patients. The Bland-Altman plots in the NIST/ISMRM phantom demonstrated an average difference of 0.001% ± 015%, 1.2% ± 7.1%, and 0.47% ± 3% between two scans from the same 3-T scanner (repeatability), and 0.002% ± 015%, 0.62% ± 10.5%, and 0.97% ± 14% between the scans acquired on two different 3-T scanners (reproducibility) for T₁ , T₂ , and T_1ρ , respectively. The in vivo knee study showed excellent repeatability with rmsCV less than 1%, 2%, and 1% for T₁ , T₂ , and T_1ρ , respectively. T_1ρ relaxation time in the mild knee OA patients was significantly higher (p < 0.05) than in healthy subjects. The proposed 3D-MRF sequence is fast, reproducible, robust to B₁ ⁺ inhomogeneity, and can simultaneously measure the T₁ , T₂ , T_1ρ , and B₁ ⁺ volumetric maps of the knee joint in a single scan within a clinically feasible scan time.

Author List

Sharafi A, Zibetti MVW, Chang G, Cloos M, Regatte RR

Author

Azadeh Sharafi PhD Assistant Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Cartilage, Articular
Humans
Knee Joint
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Osteoarthritis, Knee
Reproducibility of Results