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MR fingerprinting for rapid simultaneous T1 , T2 , and T1ρ relaxation mapping of the human articular cartilage at 3T. Magn Reson Med 2020 Nov;84(5):2636-2644

Date

05/10/2020

Pubmed ID

32385949

Pubmed Central ID

PMC7396294

DOI

10.1002/mrm.28308

Scopus ID

2-s2.0-85084363231 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

PURPOSE: To implement a novel technique for simultaneous, quantitative multiparametric mapping of the knee articular cartilage.

METHODS: A novel MR fingerprinting pulse sequence is proposed and implemented for simultaneous measurements of proton density, T1 , T2, and T1ρ relaxation times at 3T. The repeatability and reproducibility of the proposed technique were assessed in model phantoms. Institutional review board-approved MR fingerprinting imaging sequence was performed on healthy volunteers and patients with mild knee osteoarthritis. The Wilcoxon test was used to compare healthy controls and patients. The intra- and intersubject repeatability were assessed with coefficient of variation and the RMS coefficient of variation, respectively RESULTS: The Bland-Altman plots demonstrated an average difference of 4.67 ms, -0.09 ms, and 0.05 ms between 2 scans in the same scanner; and 9.68 ms, 0.29 ms, and -0.72 ms between the scans acquired on 2 different scanners for T1 , T2 , and T1ρ , respectively. The in vivo knee study showed excellent repeatability with RMS coefficient of variation less than 3%, 6%, and 5% for T1 , T2 , and T1ρ , respectively. The Wilcoxon test showed a significant difference between control and mild osteoarthritis patients for T1 (P = .04), T2 (P = .01), and T1ρ (P = .02) relaxation time in medial tibial cartilage, as well as for T2 relaxation time (P = .02) in medial femoral cartilage.

CONCLUSION: The proposed MRF sequence is fast and can simultaneously measure the T1 , T2 , T1ρ , and B1+ maps in a single scan. It is able to discriminate between mild osteoarthritis patients and healthy volunteers.

Author List

Sharafi A, Zibetti MVW, Chang G, Cloos M, Regatte RR

Author

Azadeh Sharafi PhD Assistant Professor in the Radiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Cartilage, Articular
Humans
Knee Joint
Magnetic Resonance Imaging
Osteoarthritis, Knee
Reproducibility of Results