Bi-exponential 3D-T1ρ mapping of whole brain at 3 T. Sci Rep 2018 Jan 19;8(1):1176
Date
01/21/2018Pubmed ID
29352234Pubmed Central ID
PMC5775253DOI
10.1038/s41598-018-19452-5Scopus ID
2-s2.0-85040826814 (requires institutional sign-in at Scopus site) 17 CitationsAbstract
Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer's, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40.5% of GM, and 65.1% of WM pixels showing two T1ρ relaxation pools (significance level P < 0.05). Detection of T1ρ based bi-exponential decays in the brain provides complimentary information to T2 based contrast regarding the in vivo micro-environment in the brain.
Author List
Menon RG, Sharafi A, Windschuh J, Regatte RRAuthor
Azadeh Sharafi PhD Assistant Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultBrain
Brain Mapping
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Multiple Sclerosis
Phantoms, Imaging
Young Adult
