Bi-component T1ρ and T2 Relaxation Mapping of Skeletal Muscle In-Vivo. Sci Rep 2017 Oct 26;7(1):14115
Date
10/28/2017Pubmed ID
29074883Pubmed Central ID
PMC5658335DOI
10.1038/s41598-017-14581-9Scopus ID
2-s2.0-85032491124 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
The goal of this paper was to evaluate the possibility of bi-component T1ρ and T2 relaxation mapping of human skeletal muscle at 3 T in clinically feasible scan times. T1ρ- and T2-weighted images of calf muscle were acquired using a modified 3D-SPGR sequence on a standard 3 T clinical MRI scanner. The mono- and biexponential models were fitted pixel-wise to the series of T1ρ and T2 weighted images. The biexponential decay of T1ρ and T2 relaxations was detected in ~30% and ~40% of the pixels across all volunteers, respectively. Monoexponential and bi-exponential short and long T1ρ relaxation times were estimated to be 26.9 ms, 4.6 ms (fraction 22%) and 33.2 ms (fraction: 78%), respectively. Similarly, the mono- and bi-exponential short and long T2 relaxation times were 24.7 ms, 4.2 ms (fraction 15%) and 30.4 ms (fraction 85%) respectively. The experiments had good repeatability with RMSCV < 15% and ICC > 60%. This approach could potentially be used in exercise intervention studies or in studies of inflammatory myopathies or muscle fibrosis, permitting greater sensitivity and specificity via measurement of different water compartments and their fractions.
Author List
Sharafi A, Chang G, Regatte RRAuthor
Azadeh Sharafi PhD Assistant Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultFeasibility Studies
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Monte Carlo Method
Muscle, Skeletal
