Faculty Collaboration Database

Biexponential T₂ relaxation estimation of human knee cartilage in vivo at 3T. J Magn Reson Imaging 2018 Mar;47(3):809-819

Date

06/01/2017

Pubmed ID

28561955

Pubmed Central ID

PMC5711646

DOI

10.1002/jmri.25778

Scopus ID

2-s2.0-85020043812 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

PURPOSE: To evaluate biexponential T₂ relaxation mapping of human knee cartilage in vivo in clinically feasible scan times.

MATERIALS AND METHODS: T₂ -weighted magnetic resonance (MR) images were acquired from eight healthy volunteers using a standard 3T clinical scanner. A 3D Turbo-Flash sequence was modified to enable T₂ -weighted imaging with different echo times. Series of T₂ -weighted images were fitted using mono- and biexponential models with two- and four-parametric nonlinear approaches, respectively.

RESULTS: Biexponential relaxation of T₂ was detected in the knee cartilage in five regions of interest in all eight healthy volunteers. Short/long relaxation components of T₂ were estimated to be 8.27 ± 0.68 / 45.35 ± 3.79 msec with corresponding fractions of 41.3 ± 1.1% / 58.6 ± 4.6%, respectively. The monoexponential relaxation of T₂ was measured to be 26.9 ± 2.27 msec. The experiments showed good repeatability with coefficient of variation root mean square (CV_rms ) < 18% in all regions. The only difference in gender was observed in medial tibial cartilage, where the biexponential T₂ in female volunteers was significantly higher compared to male volunteers (P = 0.014). Significant differences were observed in T₂ relaxation between different regions on interest.

CONCLUSION: Biexponential relaxation of T₂ was observed in the human knee cartilage in vivo. The short and long components are thought to be related to the tightly bound and loosely bound macromolecular water compartments. These preliminary results of biexponential T₂ analysis could potentially be used to increase the specificity for detection of early osteoarthritis by measuring different water compartments and their fractions.

LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:809-819.

Author List

Sharafi A, Chang G, Regatte RR

Author

Azadeh Sharafi PhD Assistant Professor in the Radiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Animals
Cartilage, Articular
Cattle
Feasibility Studies
Female
Humans
Image Processing, Computer-Assisted
Knee Joint
Magnetic Resonance Imaging
Male
Models, Animal
Monte Carlo Method
Reference Values
Sensitivity and Specificity