Faculty Collaboration Database

Relationship between primary colorectal tumour and location of colorectal liver metastases. ANZ J Surg 2016 May;86(5):408-10

Date

07/22/2014

Pubmed ID

25040656

DOI

10.1111/ans.12767

Scopus ID

2-s2.0-84904083118 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

BACKGROUND: There is conflicting evidence regarding whether streamlining of blood flow within the portal vein influences the anatomical distribution of colorectal liver metastases (CRLM). This study assesses the relationship between primary tumour location and metastases location.

METHODS: Patients were identified using a prospectively maintained database, and those with known site of primary colorectal tumour and hemiliver involvement were included. Site of metastases and segments affected were confirmed via review of the radiology reports. The location of primary colonic tumour was confirmed via review of clinical correspondence letters.

RESULTS: A total of 2364 metastases were identified in 891 patients. Of these, 379 metastases were in the right lobe and 156 in the left lobe, with 356 having bilobar disease. There was no significant relationship between the distribution of CRLM and the site of primary disease (left colon versus right colon) (P = 0.819). However, when the segmental location of the metastases was considered, there is a statistically significant difference between the number of right-sided CRLM compared with left-sided CRLM (P < 0.001).

CONCLUSIONS: Right-sided CRLM is more likely regardless of the primary location. Portal streaming may have an effect, although the natural anatomical 'angulation', particularly of the left portal vein branch is more likely to play a role.

Author List

Pathak S, Palkhi E, Dave R, White A, Pandanaboyana S, Prasad KR, Lodge JP, Toogood GJ

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Colorectal Neoplasms
Diagnostic Imaging
Female
Follow-Up Studies
Hepatectomy
Humans
Liver
Liver Neoplasms
Male
Middle Aged
Neoplasm Metastasis
Prospective Studies