Transplantation in adults with primary hyperoxaluria: single unit experience and treatment algorithm. Ann Transplant 2011;16(4):111-7
Date
01/03/2012Pubmed ID
22210430DOI
10.12659/aot.882227Abstract
BACKGROUND: Kidney transplantation alone in Primary Hyperoxaluria is associated with a high rate of recurrence and in many cases early graft loss. Liver transplantation offers the possibility of correcting the metabolic defect.
MATERIAL/METHODS: A retrospective review of five cases of Primary Hyperoxaluria managed at a major transplant unit was performed.
RESULTS: The 5 patients had a mean age of 32.2 years (range 28-40) at time of first transplantation. 3 patients had kidney only transplants (one live donor, 2 deceased donor) and 2 had segmental liver followed by delayed kidney transplantation. All 3 kidney alone failed and one is now awaiting a live donor transplant, one underwent kidney alone retransplantation (failed 5 years later) and one had a combined deceased donor liver and kidney transplantation (remains well at 4 years). The 2 segmental liver sequential kidney transplant recipients remain well at 1 year and 3 years.
CONCLUSIONS: Combined liver-kidney transplantation may be a better choice as the primary transplant procedure. The indication and timing for pre-emptive liver or liver followed by delayed kidney transplantation remains a matter of debate.
Author List
Malde DJ, Pararajasingam R, Tavakoli A, Campbell B, Riad H, Parrot N, Prasad KR, Augustine TAuthor
Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAlgorithms
Female
Humans
Hyperoxaluria, Primary
Kidney Transplantation
Liver Transplantation
Male
Reoperation
Retrospective Studies
Time Factors
Treatment Failure
Treatment Outcome
Young Adult
