Surgical treatment of hilar cholangiocarcinoma in a new era: comparison among leading Eastern and Western centers, Leeds. J Hepatobiliary Pancreat Sci 2010 Jul;17(4):497-504
Date
10/28/2009Pubmed ID
19859651DOI
10.1007/s00534-009-0203-6Scopus ID
2-s2.0-78651093876 (requires institutional sign-in at Scopus site) 56 CitationsAbstract
OBJECTIVE: Surgery for hilar cholangiocarcinoma (HCCA) remains challenging, with radical procedures thought to offer the best chance of long-term survival. Here we present our data for surgical resection of HCCA for the period 2001-2008.
METHODS: A prospectively maintained database was interrogated to identify all resections. Clinico-pathological data were analyzed and assessed for impact on survival.
RESULTS: 51 patients were identified. Almost three-quarters required hepatic trisectionectomy. Overall survival was 76% at 1 year, 36% at 3 years and 20% at 5 years. When R0 resection was achieved, the 5-year survival was 40%. Portal vein resection, perineural invasion and T-stage were predictive of overall survival on univariate analysis. Only T-stage remained significant on multivariate analysis. Lymph node status predicted disease-free survival.
CONCLUSION: Radical surgery continues to offer the prospect of long-term survival for patients with HCCA. Earlier detection and referral to tertiary centers may allow more patients to have potentially curative surgical resections.
Author List
Young AL, Prasad KR, Toogood GJ, Lodge JPAuthor
Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Aged, 80 and over
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Cholangiocarcinoma
Cholangiopancreatography, Endoscopic Retrograde
Cholangiopancreatography, Magnetic Resonance
Female
Follow-Up Studies
Hepatectomy
Hospitals, University
Humans
Male
Middle Aged
Neoplasm Staging
Retrospective Studies
Survival Rate
Treatment Outcome
United Kingdom
