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Quality of life after liver resection for hepatobiliary malignancies. Br J Surg 2008 Jul;95(7):845-54

Date

05/23/2008

Pubmed ID

18496887

DOI

10.1002/bjs.6180

Scopus ID

2-s2.0-47249162345 (requires institutional sign-in at Scopus site)   23 Citations

Abstract

BACKGROUND: Few prospective longitudinal studies have used a validated quality of life (QOL) instrument in patients undergoing liver resection for hepatobiliary malignancy.

METHODS: Patients undergoing liver resection for hepatobiliary tumours in a 1-year period were enrolled. The cancer-specific European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30) was completed before operation, and at 6, 12 and 36-48 months after surgery. QOL over time was analysed in relation to several clinical factors.

RESULTS: A total of 103 patients were enrolled. Patient compliance was at least 75 per cent at all stages. Most functional scales and the global QOL scale showed a non-significant trend towards deterioration at 6 months and a return to preoperative level at 12 months. Physical functioning and dyspnoea deteriorated significantly at 6 months (P = 0.020 and P = 0.004 respectively) and did not recover by 12 months (P = 0.002 and P < 0.001 respectively). Pain and fatigue showed clinically significant deterioration over 12 months, which was not statistically significant. Survivors without recurrence at 36-48 months showed better QOL than those with recurrent disease.

CONCLUSION: Major liver resection is associated with acceptable QOL outcomes, and QOL continues to improve in the long term in those without recurrence.

Author List

Dasgupta D, Smith AB, Hamilton-Burke W, Prasad KR, Toogood GJ, Velikova G, Lodge JP

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Biliary Tract Neoplasms
Chemotherapy, Adjuvant
Female
Humans
Liver Neoplasms
Male
Middle Aged
Neoplasm Recurrence, Local
Postoperative Care
Postoperative Complications
Preoperative Care
Quality of Life
Surveys and Questionnaires