Faculty Collaboration Database

Results following surgical resection for malignant pancreatic neuroendocrine tumours. A single institutional experience. JOP 2008 Jan 08;9(1):19-25

Date

01/10/2008

Pubmed ID

18182738

Scopus ID

2-s2.0-38349132990 (requires institutional sign-in at Scopus site)   22 Citations

Abstract

OBJECTIVE: The aim of the study was to present clinical outcomes of patients with malignant pancreatic neuroendocrine tumours (NET) following surgical resection with curative intent. Clinical and pathological factors that influenced the outcomes were also analysed.

DESIGN: Retrospective case note study.

PATIENTS: All patients with pancreatic NET that underwent surgery over a 7-year period (1999-2006).

RESULTS: Twelve patients were identified with a median age at diagnosis of 54 years (range: 24-79 years). Common presenting symptoms include abdominal pain (n=8) and weight loss (n=3). Overall morbidity was 25% with one post-operative death. The median follow-up period was 41 months (range: 9-156 months). The overall 2- and 5-year actuarial survival rates were 88% and 70%, respectively. The overall survival was better in patients treated with surgery compared to patients managed medically (P<0.001). The disease-free survival rates were 62% at 2 and 5 years, respectively. Recurrent disease occurred in four patients and the median disease-free interval was 6 months (range: 3-14 months). On univariate analysis, angio-invasion (P=0.015) and degree of differentiation (P=0.024) were associated with developing recurrent disease.

CONCLUSION: Surgical resection of malignant pancreatic NET results in good long-term survival in selected patients.

Author List

Bonney GK, Gomez D, Rahman SH, Verbeke CS, Prasad KR, Toogood GJ, Lodge JP, Menon KV

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Carcinoma, Neuroendocrine
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Pancreatic Neoplasms
Prognosis
Retrospective Studies
Survival Rate
Treatment Outcome