Faculty Collaboration Database

Effect of type of resection on outcome of hepatic resection for colorectal metastases. Br J Surg 2007 Oct;94(10):1242-8

Date

07/28/2007

Pubmed ID

17657718

DOI

10.1002/bjs.5640

Scopus ID

2-s2.0-35348925308 (requires institutional sign-in at Scopus site)   69 Citations

Abstract

BACKGROUND: Non-anatomical liver resections have become more common in the management of colorectal liver metastases. This study examined survival and patterns of recurrence following surgery for colorectal liver metastases.

METHODS: Data were collected prospectively on all patients who had hepatic surgery for colorectal liver metastases at St James' University Hospital, Leeds between 1993 and May 2003, and analysed with respect to type of resection.

RESULTS: A total of 96 patients underwent non-anatomical liver resection, 280 patients had an anatomical resection, and 108 patients had a combined procedure. There was no significant difference in overall survival between the anatomical and non-anatomical groups (hazard ratio 1.14 (95 per cent confidence interval 0.60 to 2.17); P = 0.691). Intrahepatic recurrence was significantly less common in the anatomical group, whereas morbidity and mortality rates were lower in the non-anatomical group. On multivariable analysis, multiple metastases and poorer primary T stage predicted poorer overall survival and a positive resection margin predicted poorer disease-free survival.

CONCLUSION: Non-anatomical resection can be performed with lower rates of surgical morbidity and mortality than anatomical resection, and does not disadvantage the patient in terms of overall survival.

Author List

Finch RJ, Malik HZ, Hamady ZZ, Al-Mukhtar A, Adair R, Prasad KR, Lodge JP, Toogood GJ

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
Disease-Free Survival
Female
Hepatectomy
Humans
Length of Stay
Liver Neoplasms
Male
Middle Aged
Neoplasm Recurrence, Local
Postoperative Complications
Prospective Studies
Risk Factors
Treatment Outcome