Faculty Collaboration Database

Biological characteristics and behaviour of putatively curatively resected colorectal liver metastases. Eur J Surg Oncol 2008 Apr;34(4):439-44

Date

05/16/2007

Pubmed ID

17502131

DOI

10.1016/j.ejso.2007.03.017

Scopus ID

2-s2.0-40749089975 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

AIM: To identify whether positive resection margin tumours had a more aggressive phenotype, using tumour micro-vessel density and invasive margin.

METHODS: Archival tissue was retrieved from 109 patients who had undergone resection for colorectal liver metastases. The nature of the invasive margin was determined by H&E histochemistry. MVD was visualised using immunohistochemical detection of CD31 antigen and quantified using image capture computer software. Clinical details and outcome were retrieved and collated with invasive margin and MVD data in a statistical database.

RESULTS: 41/68 patients with a positive resection margin (R1) had recurrences following liver resection, while only 16/41 patients with a clear margin (R0) developed recurrences. More of the margin clear patients also developed capsulated liver metastases (56%), compared to positive resection margin patients (22%) (Chi squared test p<0.001). The stromal margin MVD in the R0 patients was 250 (11-609), compared to the R1 value of 122 (27-428) (Mann-Whitney U test p=0.01).

DISCUSSION: Positive resection margin, amongst other factors, is a predictor of poor prognosis. This appears to be in part explained by the expression of adverse tumour characteristics.

Author List

Rajaganeshan R, Jayne DG, Malik HZ, Scott N, Lodge JP, Toogood GJ, Prasad KR

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Colorectal Neoplasms
Female
Hepatectomy
Humans
Liver Neoplasms
Male
Middle Aged
Neovascularization, Pathologic