Faculty Collaboration Database

Prognostic influence of multiple hepatic metastases from colorectal cancer. Eur J Surg Oncol 2007 May;33(4):468-73

Date

11/14/2006

Pubmed ID

17097260

DOI

10.1016/j.ejso.2006.09.030

Scopus ID

2-s2.0-34247126001 (requires institutional sign-in at Scopus site)   53 Citations

Abstract

AIMS: The aim of this study was to report the results of surgery for multiple colorectal liver metastases on patient outcome.

METHODS: This was a review of 484 consecutive patients who underwent liver resection for colorectal liver metastases between 1993 and 2003. The cohort was divided into 2 groups, those with 1-3 metastases and those with "multiple" metastases, namely 4 or more lesions. The later group was subdivided into those with less than 8 ("several") or 8 or more ("numerous") separate lesions.

MAIN OUTCOME MEASURES: the post-operative hospital stay was calculated and morbidity and mortality were assessed.

RESULTS: On multivariate analysis the presence of multiple metastases was the only predictor for both poorer overall survival (p=0.007) and disease-free survival (p=0.031). However, when patients with multiple metastases are analysed in detail this survival disadvantage appears to be only present in patients with numerous (8 or more) lesions.

CONCLUSION: Although patients with multiple metastases appear to have a poorer outcome, significant number of patients with multiple metastases survive to 5 years or more and should not be denied surgery. Patients with numerous (8 or more) metastases showed a poorer survival disadvantage. These patients need alternative treatment speculatives.

Author List

Malik HZ, Hamady ZZ, Adair R, Finch R, Al-Mukhtar A, Toogood GJ, Prasad KR, Lodge JP

Author

Kondragunta Rajendra Prasad MBBS Professor in the Surgery department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Chemotherapy, Adjuvant
Colorectal Neoplasms
Combined Modality Therapy
Female
Hepatectomy
Humans
Liver Neoplasms
Male
Middle Aged
Postoperative Complications
Prognosis
Retrospective Studies
Survival Rate
Treatment Outcome