Faculty Collaboration Database

Effect of inter-swallow interval on striated esophagus peristalsis; a comparative study with smooth muscle esophagus. Neurogastroenterol Motil 2023 Aug;35(8):e14608

Date

05/08/2023

Pubmed ID

37154414

Pubmed Central ID

PMC10789016

DOI

10.1111/nmo.14608

Scopus ID

2-s2.0-85158155163 (requires institutional sign-in at Scopus site)

Abstract

BACKGROUND: Effect of inter-swallow interval on the contractility of smooth muscle esophagus is well-documented. However, the effects on peristalsis of the striated esophagus have not been systematically studied. A better understanding of striated esophagus motor function in health and disease may enhance the interpretation of manometric studies and inform clinical care. The aim of this study was to assess the effect of inter-swallow interval on striated esophagus compared to findings with that of the smooth muscle esophagus.

METHODS: We performed two sets of studies to (1) determine the effect of various inter-swallow interval in 20 healthy volunteers and (2) assess the effect of ultra-short swallow intervals facilitated by straw drinking in 28 volunteers. We analyzed variables using ANOVA with Tukey's pairwise comparison and paired t-test.

KEY RESULTS: Unlike smooth muscle esophagus, the striated esophagus contractile integral did not change significantly for swallow intervals ranging from 30 to 5 s. On the contrary, striated esophagus demonstrated absent or reduced peristalsis in response to ultra-short (<2 s) intervals during straw-facilitated multiple rapid swallows.

CONCLUSIONS AND INFERENCES: Striated esophagus peristalsis is subject to manometrically observed inhibition during swallows with ultra-short intervals. Inter-swallow intervals as short as 5 s that inhibit smooth muscle esophagus peristalsis do not inhibit striated muscle peristalsis. The mechanisms of these observations are unknown but may relate to central or myenteric nervous system influences or the effects of pharyngeal biomechanics.

Author List

Edeani F, Sanvanson P, Mei L, Agrawal D, Kern M, Kovacic K, Shaker R

Authors

Dilpesh S. Agrawal MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Francis Edeani MD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Deglutition
Esophagus
Humans
Manometry
Muscle Contraction
Muscle, Smooth
Peristalsis