Extramammary Paget's disease: a novel approach to treatment using a modification of peripheral Mohs micrographic surgery. Ann Plast Surg 2012 Jun;68(6):616-20
Date
06/02/2011Pubmed ID
21629074DOI
10.1097/SAP.0b013e31821b6c7bScopus ID
2-s2.0-84861652794 (requires institutional sign-in at Scopus site) 15 CitationsAbstract
Extramammary Paget's disease is a rare intraepithelial adenocarcinoma typified histologically by the presence of Paget cells. Treatment has historically been surgical, with wide excision being the standard of care. However, due to clinically indeterminate margins and diffuse spread, local recurrence rates remain high. Mohs micrographic surgery has been proposed to improve the rate of local recurrence. Application of Mohs technique to treat extramammary Paget's disease can be difficult because of the large size of these lesions. Reported excisions either involved lengthy procedures or peripheral Mohs modification. The peripheral technique does not evaluate the depth of the central lesion, yet prognosis and lymph node involvement are directly related to the degree of vertical invasion. In this study, we discuss our experience with extramammary Paget's disease, along with a novel approach to treatment by using a modification of peripheral Mohs micrographic surgery that incorporates histologic analysis of the central specimen's depth.
Author List
O'Connor EA, Hettinger PC, Neuburg M, Dzwierzynski WWAuthor
William W. Dzwierzynski MD Professor in the Plastic Surgery department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedFemale
Genital Neoplasms, Male
Groin
Humans
Male
Middle Aged
Mohs Surgery
Paget Disease, Extramammary
Scrotum
