Faculty Collaboration Database

Inflammatory cytokines and depression symptoms following hematopoietic cell transplantation. Brain Behav Immun 2023 Aug;112:11-17

Date

05/27/2023

Pubmed ID

37236325

Pubmed Central ID

PMC10524437

DOI

10.1016/j.bbi.2023.05.012

Scopus ID

2-s2.0-85160562513 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

Increased synthesis and release of inflammatory signalling proteins is common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT) due to intensive conditioning regimens and complications such as graft-versus-host-disease and infections. Prior research indicates that inflammatory responses can activate central nervous system pathways that evoke changes in mood. This study examined relationships between markers of inflammatory activity and depression symptoms following HCT. Individuals undergoing allogeneic (n = 84) and autologous (n = 155) HCT completed measures of depression symptoms pre-HCT and 1, 3, and 6 months post-HCT. Proinflammatory (IL-6, TNF-α) and regulatory (IL-10) cytokines were assessed by ELISA in peripheral blood plasma. Mixed-effects linear regression models indicated that patients with elevated IL-6 and IL-10 reported more severe depression symptoms at the post-HCT assessments. These findings were replicated when examining both allogeneic and autologous samples. Follow-up analyses clarified that relationships were strongest for neurovegetative, rather than cognitive or affective, symptoms of depression. These findings suggest that anti-inflammatory therapeutics targeting an inflammatory mediator of depression could improve quality of life of HCT recipients.

Author List

Nelson AM, Erdmann AA, Coe CL, Juckett MB, Morris K, Knight JM, Hematti P, Costanzo ES

Authors

Peiman Hematti MD Professor in the Medicine department at Medical College of Wisconsin
Jennifer M. Knight MD, MS Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cytokines
Depression
Hematopoietic Stem Cell Transplantation
Humans
Interleukin-10
Interleukin-6
Quality of Life