Faculty Collaboration Database

The effect of topical vasodilating agents on microvascular vessel diameter in the rat model. Laryngoscope 1996 Nov;106(11):1429-33

Date

11/01/1996

Pubmed ID

8914915

DOI

10.1097/00005537-199611000-00024

Scopus ID

2-s2.0-0029903492 (requires institutional sign-in at Scopus site)   28 Citations

Abstract

Topical vasodilating agents maximize blood flow and prevent vasospasm in microvascular tissue-transfer procedures. Two commonly used agents are papaverine and lidocaine. Although these drugs have vasodilating properties, no studies have directly compared their vasodilating abilities in a controlled, in vivo model. We used videomicroscopy and direct microscopic measurements to compare the vasodilating capacity of papaverine, 1% lidocaine, and saline solution in the femoral artery of Sprague-Dawley rats. Degree of maximum dilation, ability to sustain dilation, average dilation over a 10-minute period, and time to achieve maximum dilation were considered. Both papaverine and lidocaine were found to be superior to saline solution as vasodilating agents. Papaverine was found to sustain vasodilation longer than lidocaine, suggesting that it is a superior vasodilating agent in microvascular anastomoses.

Author List

Kerschner JE, Futran ND

Author

Joseph E. Kerschner MD Provost, Executive Vice President, Dean, Professor in the School of Medicine Administration department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Administration, Topical
Animals
Femoral Artery
Lidocaine
Male
Microscopy, Video
Papaverine
Rats
Rats, Sprague-Dawley
Sodium Chloride
Time Factors
Vasodilator Agents