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Impaired immune function in a premature infant with zinc deficiency after total parenteral nutrition. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1996 Sep-Oct;37(5):364-9

Date

09/01/1996

Pubmed ID

8942032

Abstract

The report describes a premature infant with necrotizing enterocolitis who developed symptoms of zinc (Zn) deficiency after three to four weeks of total parenteral nutrition (TPN). Clinical presentations included characteristic skin rash, alopecia, retarded growth, generalized edema and decreased serum alkaline phosphatase (ALP). Immune function studies revealed impaired neutrophil adhesion and mitogen-induced lymphoproliferation, whereas phagocytosis, chemotaxis and lymphocyte subsets remained normal. A high dose of elemental Zn (2.5 mg/kg/day), administered orally, improved the clinical symptoms and restored the immune function. In patients with Zn deficiency, impaired neutrophil adhesion and lymphocyte function may contribute to immunodeficiency which can be reversed with adequate Zn supplementation.

Author List

Fan PC, Teng RJ, Chou CC, Wu TJ, Tsou Yau KI, Hsieh KH

Authors

Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tzong-Jin Wu MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Humans
Infant
Infant, Newborn
Infant, Premature
Lymphocyte Activation
Male
Neutrophils
Parenteral Nutrition, Total
Zinc
jenkins-FCD Prod-486 e3098984f26de787f5ecab75090d0a28e7f4f7c0