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Longitudinal analysis of pulmonary function in adults with sickle cell disease. Am J Hematol 2008 Jul;83(7):574-6

Date

04/03/2008

Pubmed ID

18383325

Pubmed Central ID

PMC3729267

DOI

10.1002/ajh.21176

Scopus ID

2-s2.0-45749146298 (requires institutional sign-in at Scopus site)   30 Citations

Abstract

Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.

Author List

Field JJ, Glassberg J, Gilmore A, Howard J, Patankar S, Yan Y, Davies SC, Debaun MR, Strunk RC

Author

Joshua J. Field MD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Aged
Anemia, Sickle Cell
Female
Humans
Longitudinal Studies
Lung
Male
Middle Aged