Longitudinal analysis of pulmonary function in adults with sickle cell disease. Am J Hematol 2008 Jul;83(7):574-6
Date
04/03/2008Pubmed ID
18383325Pubmed Central ID
PMC3729267DOI
10.1002/ajh.21176Scopus ID
2-s2.0-45749146298 (requires institutional sign-in at Scopus site) 30 CitationsAbstract
Among adults with sickle cell disease (SCD), pulmonary complications are a leading cause of death. Yet, the natural history of lung function in adults with SCD is not well established. We conducted a retrospective cohort study of adults with SCD who had repeated pulmonary function tests performed over 20 years of age. Ninety-two adults were included in this cohort. Rate of decline in FEV(1) for men and women with SCD was 49 cc/year (compared with 20-26 cc/year in the general population). Further studies are needed to identify factors which impact the rate of lung function decline in adults with SCD.
Author List
Field JJ, Glassberg J, Gilmore A, Howard J, Patankar S, Yan Y, Davies SC, Debaun MR, Strunk RCAuthor
Joshua J. Field MD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Anemia, Sickle Cell
Female
Humans
Longitudinal Studies
Lung
Male
Middle Aged