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Primary skeletal Ewing's sarcoma in Down syndrome. Cancer Genet Cytogenet 1990 Jul 01;47(1):61-8

Date

07/01/1990

Pubmed ID

2141543

DOI

10.1016/0165-4608(90)90263-a

Abstract

Primary skeletal Ewing's sarcoma that occurred in two teenage patients with Down syndrome are reported. Cytogenetic analysis of one of these tumors showed the 11;22 translocation characteristic of Ewing's sarcoma as well as other complex karyotypic changes. The possible role of constitutional trisomy 21 in development of these sarcomas is discussed.

Author List

Bridge JA, Neff JR, Borek DA, Hackbarth DA

Author

Donald A. Hackbarth Jr MD Professor in the Orthopaedic Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Bone Neoplasms
Chromosome Banding
Down Syndrome
Female
Humans
Karyotyping
Male
Sarcoma, Ewing