Faculty Collaboration Database

Association between body mass index at diagnosis and pediatric leukemia mortality and relapse: a systematic review and meta-analysis. Leuk Lymphoma 2016 May;57(5):1140-8

Date

10/11/2015

Pubmed ID

26453440

DOI

10.3109/10428194.2015.1076815

Scopus ID

2-s2.0-84949771352 (requires institutional sign-in at Scopus site)   43 Citations

Abstract

Obesity is a risk factor for mortality and relapse of certain cancers. However, existing evidence for pediatric leukemia is inconsistent. The aim of this systematic review and meta-analysis was to evaluate the association between obesity at diagnosis and pediatric acute leukemia mortality and relapse. This study systematically searched MEDLINE and EMBASE from inception to February 5, 2015. Random-effect models were used to generate pooled estimates of study-specific hazard ratios (HR) and 95% confidence intervals (CI). Eleven studies were included. An increased risk of mortality with a high BMI at diagnosis was observed (overall survival: HR=1.30, 95% CI=1.16-1.46 and event-free survival: HR=1.46, 95% CI=1.29-1.64). Only two studies reported HR for relapse; one reported a reduced risk, while the other reported an increased risk. A high BMI at diagnosis is associated with poor overall and event-free survival among pediatric acute leukemia patients. Targeted therapeutic approaches for obese pediatric leukemia patients may potentially improve survival outcomes.

Author List

Amankwah EK, Saenz AM, Hale GA, Brown PA

Author

Ernest Amankwah PhD Director, Associate Professor in the Clinical and Translational Science Institute department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Body Mass Index
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Leukemia
Male
Mortality
Obesity
Proportional Hazards Models
Publication Bias
Recurrence