Faculty Collaboration Database

Time-multiplexed beamforming for noninvasive microwave hyperthermia treatment. IEEE Trans Biomed Eng 2011 Jun;58(6):1574-84

Date

01/11/2011

Pubmed ID

21216700

DOI

10.1109/TBME.2010.2103943

Scopus ID

2-s2.0-79956352164 (requires institutional sign-in at Scopus site)   47 Citations

Abstract

A noninvasive microwave beamforming strategy is proposed for selective localized heating of biological tissue. The proposed technique is based on time multiplexing of multiple beamformers. We investigate the effectiveness of the time-multiplexed beamforming in the context of brain hyperthermia treatment by using a high-fidelity numerical head phantom of an adult female from the Virtual Family (IT'IS Foundation) as our testbed. An operating frequency of 1 GHz is considered to balance the improved treatment resolution afforded by higher frequencies against the increased penetration through the brain afforded by lower frequencies. The exact head geometry and dielectric properties of biological tissues in the head are assumed to be available for the creation of patient-specific propagation models used in beamformer design. Electromagnetic and thermal simulations based on the finite-difference time-domain method are used to evaluate the hyperthermia performance of time-multiplexed beamforming and conventional beamforming strategies. The proposed time-multiplexing technique is shown to reduce the unintended heating of healthy tissue without affecting the treatment temperature or volume. The efficacy of the method is demonstrated for target locations in three different regions of the brain. This approach has the potential to improve microwave-induced localized heating for cancer treatment via hyperthermia or heat-activated chemotherapeutic drug release.

Author List

Zastrow E, Hagness SC, Van Veen BD, Medow JE

Author

Joshua E. Medow MD Professor in the Neurology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adult
Brain Neoplasms
Female
Humans
Hyperthermia, Induced
Microwaves
Models, Theoretical
Phantoms, Imaging
Radiotherapy Planning, Computer-Assisted
Signal Processing, Computer-Assisted