MicroRNAs in cancer: glioblastoma and glioblastoma cancer stem cells. Neurochem Int 2014 Nov;77:68-77
Date
06/18/2014Pubmed ID
24937770Pubmed Central ID
PMC4390175DOI
10.1016/j.neuint.2014.06.002Scopus ID
2-s2.0-84907580505 (requires institutional sign-in at Scopus site) 73 CitationsAbstract
MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their dysregulation plays major roles in many cancer types. Gliomas are cancers arising from the central nervous system. The most malignant and common glioma is glioblastoma multiforme (GBM), and even with aggressive treatment (surgical resection, chemotherapy, and radiation), average patient survival remains less than 2 years. In this review we will summarize the current findings regarding microRNAs in GBM and the biological and clinical implications of this data.
Author List
Brower JV, Clark PA, Lyon W, Kuo JSAuthor
Will Lyon MD Assistant Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBrain Neoplasms
Glioblastoma
Humans
MicroRNAs
Neoplasms
Neoplastic Stem Cells
