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Female reproductive health in pediatric, adolescent, and young adult cancer survivors. Pediatr Blood Cancer 2023 Sep;70 Suppl 5:e29170

Date

06/29/2023

Pubmed ID

37381166

DOI

10.1002/pbc.29170

Scopus ID

2-s2.0-85163671746 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

An estimated 500,000 cancer survivors of reproductive age in the United States will live to experience the long-term consequences of cancer treatment. Therefore, a focused aspect of cancer care has appropriately shifted to include quality of life in survivorship. Infertility is a late effect of therapy that affects 12% of female survivors of childhood cancer receiving any cancer treatment in large cohort studies and results in a 40% decreased likelihood of pregnancy in young adults of ages 18-39 years. Nonfertility gynecologic late effects such as hypoestrogenism, radiation-induced uterine and vaginal injury, genital graft-versus-host disease after hematopoietic stem cell transplant, and sexual dysfunction also significantly affect quality of life in survivorship but are underdiagnosed and require consideration. Several articles in the special edition "Reproductive Health in Adolescent and Young Adult Cancer Survivorship" address infertility, genital graft-versus-host disease, and psychosexual functioning in survivorship. This review article focuses on other adverse gynecologic outcomes of cancer therapies including hypogonadism and hormone replacement therapy, radiation-induced uterovaginal injury, vaccination and contraception, breast and cervical cancer screening, and pregnancy considerations in survivorship.

Author List

Hoefgen HR, Benoit J, Chan S, Jayasinghe Y, Lustberg M, Pohl V, Saraf A, Schmidt D, Appiah LC

Author

Debra Schmidt NP APP Hybrid in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Cancer Survivors
Child
Early Detection of Cancer
Female
Graft vs Host Disease
Humans
Infertility
Neoplasms
Pregnancy
Quality of Life
Reproductive Health
Uterine Cervical Neoplasms
Young Adult