Molecular-enriched functional connectivity in the human brain using multiband multi-echo simultaneous ASL/BOLD fMRI. Sci Rep 2023 Jul 20;13(1):11751
Date
07/21/2023Pubmed ID
37474568Pubmed Central ID
PMC10359289DOI
10.1038/s41598-023-38573-0Scopus ID
2-s2.0-85165341158 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
Receptor-enriched analysis of functional connectivity by targets (REACT) is a strategy to enrich functional MRI (fMRI) data with molecular information on the neurotransmitter distribution density in the human brain, providing a biological basis to the functional connectivity (FC) analysis. Although this approach has been used in BOLD fMRI studies only so far, extending its use to ASL imaging would provide many advantages, including the more direct link of ASL with neuronal activity compared to BOLD and its suitability for pharmacological MRI studies assessing drug effects on baseline brain function. Here, we applied REACT to simultaneous ASL/BOLD resting-state fMRI data of 29 healthy subjects and estimated the ASL and BOLD FC maps related to six molecular systems. We then compared the ASL and BOLD FC maps in terms of spatial similarity, and evaluated and compared the test-retest reproducibility of each modality. We found robust spatial patterns of molecular-enriched FC for both modalities, moderate similarity between BOLD and ASL FC maps and comparable reproducibility for all but one molecular-enriched functional networks. Our findings showed that ASL is as informative as BOLD in detecting functional circuits associated with specific molecular pathways, and that the two modalities may provide complementary information related to these circuits.
Author List
Dipasquale O, Cohen A, Martins D, Zelaya F, Turkheimer F, Veronese M, Mehta MA, Williams SCR, Yang B, Banerjee S, Wang YAuthor
Yang Wang MD Professor in the Radiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
BrainBrain Mapping
Cerebrovascular Circulation
Humans
Magnetic Resonance Imaging
Reproducibility of Results
