Faculty Collaboration Database

[Conventional and novel cardiovascular risk factors and predisposition to the development of atherosclerosis]. Patol Fiziol Eksp Ter 2015;59(1):4-11

Date

08/01/2015

Pubmed ID

26226683

Scopus ID

2-s2.0-84999136499 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

This population-based cross-sectional study included 472 apparently healthy study participants with an increased risk of cardiovascular disease, including 300 patients with hypercholesterolemia. To assess the susceptibility to the development of atherosclerosis, an ultrasonic evaluation of common carotid arteries was used. It has been confirmed that there exists the geographical gradient of carotid intima-media thickness (cIMT), and it has been shown that this gradient is highly correlated th the known gradient of cardiovascular mortality. It was found that the combination of conventional cardiovascular risk factors can help explaining only 21% variability of cIMT, the marker of generalized atherosclerosis. It was found that a predisposition to atherosclerosis, as measured by a pathological increase in cIMT, should be due to the interaction not only conventional cardiovascular risk factors, but also to genetic and environmental factors.

Author List

Sobenin IA, Zhelankin AV, Chernova EV, Kirichenko TV, Safarova MS, Sergienko IV, Doroshchuk AD, Trubinov SS, Karagodin VP, Orekhov AN

Author

Maya S. Safarova MD, PhD Assistant Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Aged
Atherosclerosis
Carotid Intima-Media Thickness
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Risk Factors